161+ Rental Villas and Private Getaways in Santee |
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Santee Vacation Rentals & One Degree Stays Homes

About Santee Vacation Rentals

There are more than 161 vacation rentals that are available in Santee. These rentals, including vacation rentals, One Degree Stays Homes (ODSs) and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at an ODS property in Santee.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With OneDegreeStays Santee, you have the flexibility of comparing different options of various deals with a single click. Looking for an ODS with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner (ODSs), and other popular Airbnb-style properties in Santee. Places to stay near Santee are 336.92 ft² on average, with prices averaging US $294 a night.

OneDegreeStays makes it easy and safe to find and compare vacation rentals in Santee with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

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Top Rental Accommodation Types in Santee

Type Count
Vacation Homes 17
Holiday Apartments 3
Cottages 1

Use these Quick Filters to Find a Vacation Rental in Santee

★ Pro Tip: OneDegreeStays makes it easy to compare the best listings on ODS homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between ODS homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Santee.

Weather in Santee, SC

View the weather forecast for Santee before booking your Santee Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Top Attractions Around Santee, SC

OneDegreeStays offers a large selection of top attractions around Santee. Research things to do on your vacation before you visit Santee.


Santee State Park
Santee Cooper Country Club
Santee Outlets
Santee National Golf Club
Lake Marion
Congaree National Park
South Carolina State University
Lake Moultrie
St. George United Methodist Church
Santee National Wildlife Refuge
Wyboo Golf Club
I.P. Stanback Museum & Planetarium
Taw Caw Creek Park
Taw Caw Creek
Foxboro Golf Club
Potato Creek
Jennie J McMahan Library
Poinsett State Park

Other Places to Stay in Santee, SC


Santee Cooper Country Club 100 Properties
Santee Outlets 98 Properties
Santee National Golf Club 94 Properties
Santee State Park 66 Properties

Frequently Asked Questions About Santee?

What are the top vacation rentals in Santee?

There are a lot of options in Santee. If you plan on staying in the Santee area, consider making a reservation for a few nights at one of these properties as these have been rated the Top Vacation Rentals in Santee:

How many vacation rentals have private pools in Santee?

There are 4 vacation rentals with private pools near Santee. Top-rated ODS homes that have access to a swimming pool include:

Which vacation homes in Santee are best for families?

If you are looking for a family-friendly vacation home in Santee, check out one of the following properties as all are highly-rated places to stay with excellent review for families or groups staying in Santee:

How many onedegreestays vacation rentals are available in Santee?

Currently, the total number of properties listed by One Degree Stays in 2025 is over 161 in the Santee area, and still counting. By aggregating listings from multiple websites, One Degree Stays offers an immense amount of choice of the best ODS properties in Santee. 


People Also Ask

There are 161 Santee, SC Vacation Rentals

Recently Booked Vacation Rentals in Santee